Sex-specific genetic effect of discovered loci.

Currant, Hannah; Hysi, Pirro; Fitzgerald, Tomas W.; Gharahkhani, Puya; Bonnemaijer, Pieter W. M.; Senabouth, Anne; Hewitt, Alex W.; Atan, Denize; Aung, Tin; Charng, Jason; Choquet, Hélène; Craig, Jamie; Khaw, Peng T.; Klaver, Caroline C. W.; Kubo, Michiaki; Ong, Jue-Sheng; Pasquale, Louis R.; Reisman, Charles A.; Daniszewski, Maciej; Powell, Joseph E.; Pébay, Alice; Simcoe, Mark J.; Thiadens, Alberta A. H. J.; van Duijn, Cornelia M.; Yazar, Seyhan; Jorgenson, Eric; MacGregor, Stuart; Hammond, Chris J.; Mackey, David A.; Wiggs, Janey L.; Foster, Paul J.; Patel, Praveen J.; Birney, Ewan; Khawaja, Anthony P.

doi:10.1371/journal.pgen.1009497.s011

pgen.1009497.s011.pdf (12.14 kB)

Sex-specific genetic effect of discovered loci.

journal contribution

posted on 2021-05-12, 17:47 authored by Hannah Currant, Pirro Hysi, Tomas W. Fitzgerald, Puya Gharahkhani, Pieter W. M. Bonnemaijer, Anne Senabouth, Alex W. Hewitt, Denize Atan, Tin Aung, Jason Charng, Hélène Choquet, Jamie Craig, Peng T. Khaw, Caroline C. W. Klaver, Michiaki Kubo, Jue-Sheng Ong, Louis R. Pasquale, Charles A. Reisman, Maciej Daniszewski, Joseph E. Powell, Alice Pébay, Mark J. Simcoe, Alberta A. H. J. Thiadens, Cornelia M. van Duijn, Seyhan Yazar, Eric Jorgenson, Stuart MacGregor, Chris J. Hammond, David A. Mackey, Janey L. Wiggs, Paul J. Foster, Praveen J. Patel, Ewan Birney, Anthony P. Khawaja

A boxplot of the mean thickness of the RNFL across the Macula 6 gird and across the left and right eyes stratified by genetically determined sex and genotype at rs146652416 (FOXG1). Genotype is encoded as homozygous reference (0), heterozygous (1) and homozygous alternative (2). A linear model of RNFL thickness including each discovered SNP and an interaction term between the SNP and genetically determined sex had a statistically significant sex-specific effect for rs146652416 (P = 8.08 × 10^-4).

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