posted on 2024-01-08, 16:09authored byGeunseon Park, Woonsung Na, Jong-Woo Lim, Chaewon Park, Sojeong Lee, Minjoo Yeom, Eulhae Ga, Jaehyun Hwang, Suyun Moon, Dae Gwin Jeong, Hyoung Hwa Jeong, Daesub Song, Seungjoo Haam
Infectious diseases pose persistent threats to public
health, demanding
advanced vaccine technologies. Nanomaterial-based delivery systems
offer promising solutions to enhance immunogenicity while minimizing
reactogenicity. We introduce a self-assembled vaccine (SAV) platform
employing antigen-polymer conjugates designed to facilitate robust
immune responses. The SAVs exhibit efficient cellular uptake by dendritic
cells (DCs) and macrophages, which are crucial players in the innate
immune system. The high-density antigen presentation of this SAV platform
enhances the affinity for DCs through multivalent recognition, significantly
augmenting humoral immunity. SAV induced high levels of immunoglobulin
G (IgG), IgG1, and IgG2a, suggesting that mature DCs efficiently induced
B cell activation through multivalent antigen recognition. Universality
was confirmed by applying it to respiratory viruses, showcasing its
potential as a versatile vaccine platform. Furthermore, we have also
demonstrated strong protection against influenza A virus infection
with SAV containing hemagglutinin, which is used in influenza A virus
subunit vaccines. The efficacy and adaptability of this nanostructured
vaccine present potential utility in combating infectious diseases.