posted on 2021-05-12, 04:29authored byHaihong Niu, Xiaoxue Hou, Yanli Zhang, Xiaohui Wu, Fei Deng, Fan Huang, Linqi Shi, Rujiang Ma
Human
islet amyloid polypeptide (hIAPP) aggregation is closely
associated with dysfunction and apoptosis of pancreatic β-cells
in type 2 diabetes (T2D). Accordingly, hIAPP amyloid inhibitors have
shown promise against T2D. Here, by mimicking the function of natural
molecular chaperones, nanochaperones (nChaps) based on self-assembled
polymeric micelles with tunable surface microdomains for T2D treatment
are reported. By capturing the aggregation-prone species of hIAPP
onto the hydrophobic microdomains and segregating them by hydrophilic
PEG chains, this kind of nChaps could effectively prevent hIAPP aggregation,
block cell adhesion of hIAPP, facilitate hIAPP aggregates degradation
and reduce hIAPP-related cytotoxicity. Therefore, our work will provide
useful insights to develop a biomimetic strategy for the treatment
of T2D.