Selenated NHC-Pd(II)
Pincer Complex Catalyzed, Temperature-Dependent
Selective Hydroamination and Oxidative Amination of Olefins: Formation
of Enamine Esters and β‑Amino Esters under Solvent-Free
and Aerobic Conditions
posted on 2023-12-12, 11:29authored byCharu Sharma, Sangeeta Kumari, Deepak Sharma, Avinash K. Srivastava, Raj K. Joshi
NHC-Pd(II) pincer catalyzed oxidative amination and hydroamination
of olefins is developed under solvent-free aerobic conditions. Reaction
offered a temperature-controlled synthesis of (Z)-enamine
and β-amino esters to provide easy access and remarkable functional
group tolerance for a variety of enamines. The developed approach
renders an opportunity of scalability and flexibility, and besides
this, the produced enamines can be transformed into many N-containing
heterocycles, underscoring its potential usage in synthetic and pharmaceutical
chemistry. Moreover, it is the first report for coupling of aniline
with styrene.