Selectfluor-Mediated
Synthesis of β‑Acyl
Allyl Sulfones/β-Acyl Allyl Benzotriazoles from Ketones/Acetylenes,
Aryl Sulfinates/Benzotriazole, and DMSO as a Dual-Carbon Synthon
posted on 2022-01-13, 20:33authored bySaradhi Kalari, Uttam B. Karale, Haridas B. Rode
A Selectfluor-mediated
approach for the synthesis of β-acyl
allyl sulfones/β-acyl allyl benzotriazoles with excellent atom
economy from readily available acetophenones/aryl acetylenes, aryl
sulfinates/benzotriazoles, and dimethyl sulfoxide (DMSO) is described.
In this protocol, DMSO acts as a dual-carbon synthon, resulting in
a transition-metal-free construction of two C–C and one C–S
or two C–C and one C–N bonds in one pot. This approach
is extended to generate chemically diverse compounds. Additionally,
β-acyl allyl sulfones/β-acyl allyl benzotriazoles were
prepared from acetylenes instead of acetophenones.