figshare
Browse
pgen.1009736.s004.pdf (6.5 MB)

S4 Fig -

Download (6.5 MB)
journal contribution
posted on 2021-09-07, 17:41 authored by Wenfan Ke, Jordan N. Reed, Chenyu Yang, Noel Higgason, Leila Rayyan, Carolina Wählby, Anne E. Carpenter, Mete Civelek, Eyleen J. O’Rourke

LocusZoom plots of the associations of the SNPs near ACP2 with (A) BMI and (B) ACP2 gene expression in subcutaneous adipose tissue in the METSIM cohort. The effect of the alleles of rs10501321 on (C) ACP2 expression and (D) total triglycerides. (E) Correlation between BMI and ACP2 (human pho-1 ortholog) expression in the METSIM cohort.

(PDF)

History

Usage metrics

    PLOS Genetics

    Categories

    Keywords

    identifying pharmacological targetsfar merely correlatedectopic fat depotsdiv >< passociated metabolic syndromemodel systems compatiblereport 14 genescandidate genes reportedobesity across phylogenywide association studiescausal obesity genesthroughput genetic screening3 dio geneshuman obesity loci3 geneshuman obesityrnai screeninginvertebrate modelprevent diodio ).several genesortholog genesgenes would293 genespromote obesityinduced obesityvivo study demonstratesrnai screenedphenotypic outcomeoverconsuming fructosenext challengeleading causeincreased interestidentified hundredshumans matchesheavy burdenhealthcare systemexperimentally defineelegans disease ’defining causalitycausally linkedcausality 293c also improves

    Licence

    CC BY 4.0

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC