pcbi.1009579.s003.pdf (400.83 kB)
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posted on 2021-11-19, 18:37 authored by Takeru Fujii, Kazumitsu Maehara, Masatoshi Fujita, Yasuyuki Ohkawa(a) The scRNA-seq data embedded into two-dimensional space with UMAP. (b) ”POI” and “Others” determined by the Louvain algorithm. POI corresponds to the cluster of hematopoietic precursor cells. (c) The Strong features contain many genes that are the markers of POI. The results of GO enrichment analysis for the Strong features. GOs are ordered by the contained proportion of Strong feature genes. (d) Zoom in on the area indicated in Fig S3b. Cells expressing Niche features (Calcr, Edn3, and Gm12603) are highlighted.
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xlink "> organismsupon recent advancesperform binary classificationfrequently used methodfaced difficulties associateddifferentially expressed geneadaptive lasso penaltyidentifying marker genesmean expression levelsvarious cell typesdfc enabled characterizationprogenitor cell populationgenes cell typescell characterizationcell populationcell analysisdefining genesvariable selectionthroughput analysisstatistical testsspecific statesspecific markerssmall subsetsample sizeresults revealedpotential applicationsmuscle satelliteeffectively subjecteddiscriminative featurediscriminative approachdfc ),comprehensive understandingbased approachesbased analysis
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