ppat.1012050.s002.pdf (138.97 kB)
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posted on 2024-02-29, 18:55 authored by Sydney Stanley, Xin Wang, Qingyun Liu, Young Yon Kwon, Abigail M. Frey, Nathan D. Hicks, Andrew J. Vickers, Sheng Hui, Sarah M. FortuneComparison of the area under the curve for the growth curves shown in Fig 3D (A), Fig 3F (B), and Fig 4D (C). Three replicates are shown, error bars indicate the standard deviation. P-values indicate the results of an ordinary one-way ANOVA with Dunnett’s multiple comparison test. Representative of two independent experiments.
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providing experimental evidencediv >< pcentral carbon metabolism1 virulence systemmycobacterium tuberculosis discernible growth defectdependent antibiotic susceptibilitymutations functionally increasehuman host environmentglobal clinical isolateslactate dehydrogenase revealsassessing mtb genes13 clinical isolatesvivo mtb growthlactate dehydrogenaseintracellular environmenthost pressuregenes involveddependent lvariation acrosstranscriptionally sensitivesugar phosphatesstrongest targetsstepwise natureselective advantagesalient featurerobust incorporationprovides contextpressures facingpoorly characterizedpleiotropic effectsmycobacterial cellmultifunctional rolemtb genomelldd2 lactate accumulationfunctional reporterdetoxification benefitdeleterious buildupdefining mutationsdata illustratebacterial determinantsbacterial adaptionancestral lineage
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