pgen.1011060.s006.pdf (625.93 kB)
S2 Fig -
journal contribution
posted on 2023-12-06, 18:35 authored by Kelley Hurst-Hess, Charity McManaman, Yong Yang, Shamba Gupta, Pallavi Ghosh(a-d) Growth of ten-fold serial dilutions of M. abscessus ATCC 19977, ΔMabwhiB7, and ΔMabwhiB7 complemented with indicated genes on Middlebrook 7H10 plates containing indicated concentrations of antibiotics. Data is representative of >3 independent experiments.
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observed hypersensitivity δmabmajor hub controllingwhib7 functions exclusivelymycobacterium abscessus gene expression withinabscessus genes withinwhib7 demonstratingwhib7 transcriptional activatortargeting antibioticsresults suggestpromoters recognizedpresent workpoorly understoodmajor roleknown determinantsintrinsically resistantinterconnected networksinduced expressionindividual contributionshowever unknownhflx erm41 eis2 cumulative effectantibiotics effectiveantibiotic stress
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