pgen.1011012.s010.pdf (205.71 kB)
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posted on 2023-11-06, 18:30 authored by Jing Li, Simon Stenberg, Jia-Xing Yue, Ekaterina Mikhalev, Dawn Thompson, Jonas Warringer, Gianni LitiThe dynamics of relative yield of all the (A) YPD-evolved, (B) HU-evolved, and (C) RM-evolved MALs across five time points during mutation accumulation. The green, blue, and orange dots show the relative yield measured in YPD, HU and RM condition respectively while the grey dots show the yield of drug-evolved MALs phenotyped in drug-free condition. “*” indicates mtDNA loss.
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mutational processes dictatingincluding mtdna deletionsresolved growth phenotypinghydroxyurea also inducedmutation rates dependedparticularly high occurrencehydroxyurea mutation footprintgenome instability footprintdramatic fitness lossmutation ratescell growthxlink ">wide rangeused wholetransversion ratetaken togetherstudy providesstructural variantsremarkable exceptionmutagenic effectsmarginally affectedimportant implicationsgenome sequencinggenetic backgroundsgenetic backgroundgave riseelevated regardlessdisease treatmentdetailed viewdepth viewchronic effectscell fitnessbroad rangebrings insightsaccurate quantification
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