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Fig A. Summary of HBV infection datasets. Fig B. Correlation between the biomarkers and cccDNA. Fig C. Fitting of the mathematical model to the extracellular viral markers in peripheral blood of humanized mice treated with ETV or PEG IFN-α considering HBsAg production from iDNA. Table D. Estimated parameters for HBV infection in humanized mouse considering HBsAg production from iDNA. Table E. Fixed initial values for HBV infection in humanized mouse. Table F. Quantified results for cccDNA in HBV-infected mouse. Note G. Transformation to a system of ODEs from a PDE multiscale model. Note H. Linearized equations under potent NAs treatment in humanized mouse. Note I. Linearized equations under potent PEG IFN-α treatment in humanized mouse.

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