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Lim, Lee-Ling; Hussein, Zanariah; Noor, Nurain Md; Raof, Anis S. Abd; Mustafa, Norlaila; Bidin, Mohamed B. Long; Ghani, Rohana Abdul; Samsuddin, Syahrizan; Yong, Sy-Liang; Foo, Siew-Hui; Raghuram, Kavitha; Suwannasri, Payiarat; B., Wan Mohamad W.; Chiew, Thiam-Kian; Chan, Siew-Pheng

doi:10.1371/journal.pone.0296298.s001

pone.0296298.s001.docx (65.63 kB)

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journal contribution

posted on 2024-01-02, 18:58 authored by Lee-Ling Lim, Zanariah Hussein, Nurain Md Noor, Anis S. Abd Raof, Norlaila Mustafa, Mohamed B. Long Bidin, Rohana Abdul Ghani, Syahrizan Samsuddin, Sy-Liang Yong, Siew-Hui Foo, Kavitha Raghuram, Payiarat Suwannasri, Wan Mohamad W. B., Thiam-Kian Chiew, Siew-Pheng Chan

Aim

Given a lack of data on diabetes care performance in Malaysia, we conducted a cross-sectional study to understand the clinical characteristics, control of cardiometabolic risk factors, and patterns of use of guideline-directed medical therapy (GDMT) among patients with type 2 diabetes (T2D), who were managed at publicly-funded hospitals between December 2021 and June 2022.

Methods

Patients aged ≥18 years with T2D from eight publicly-funded hospitals in the Greater Kuala Lumpur region, who had ≥2 outpatient visits within the preceding year and irrespective of treatment regimen, were eligible. The primary outcome was ≥2 treatment target attainment (defined as either HbA_1c <7.0%, blood pressure [BP] <130/80 mmHg, or low-density lipoprotein cholesterol [LDL-C] <1.8 mmol/L). The secondary outcomes were the individual treatment target, a combination of all three treatment targets, and patterns of GDMT use. To assess for potential heterogeneity of study findings, all outcomes were stratified according to prespecified baseline characteristics namely 1) history of atherosclerotic cardiovascular disease (ASCVD; yes/no) and 2) clinic type (Diabetes specialist versus General medicine).

Results

Among 5094 patients (mean±SD age 59.0±13.2 years; T2D duration 14.8±9.2 years; HbA_1c 8.2±1.9% (66±21 mmol/mol); BMI 29.6±6.2 kg/m²; 45.6% men), 99% were at high/very high cardiorenal risk. Attainment of ≥2 treatment targets was at 18%, being higher in General medicine than in Diabetes specialist clinics (20.8% versus 17.5%; p = 0.039). The overall statin coverage was 90%. More patients with prior ASCVD attained LDL-C <1.4 mmol/L than those without (13.5% versus 8.4%; p<0.001). Use of sodium-glucose cotransporter-2 (SGLT2) inhibitors (13.2% versus 43.2%), glucagon-like peptide-1 receptor agonists (GLP1-RAs) (1.0% versus 6.2%), and insulin (27.7% versus 58.1%) were lower in General medicine than in Diabetes specialist clinics.

Conclusions

Among high-risk patients with T2D, treatment target attainment and use of GDMT were suboptimal.