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Formica, Neil; Mallory, Raburn; Albert, Gary; Robinson, Michelle; Plested, Joyce S.; Cho, Iksung; Robertson, Andreana; Dubovsky, Filip; Glenn, Gregory M.

doi:10.1371/journal.pmed.1003769.s001

pmed.1003769.s001.doc (104 kB)

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posted on 2021-10-01, 17:22 authored by Neil Formica, Raburn Mallory, Gary Albert, Michelle Robinson, Joyce S. Plested, Iksung Cho, Andreana Robertson, Filip Dubovsky, Gregory M. Glenn

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unsolicited adverse events nanoparticle vaccine composed key secondary endpoint 50 %— mn 4 vaccine groups study limitations include 2 intramuscular doses 5 -&# 956 5 &# 956 receive either 1 283 participants administered spike protein response 2 spike glycoproteins showed sufficient immunogenicity relatively short duration phase 2 component geometric mean titers also well tolerated second dose ).different dose regimens 21 days apart phase 1 findings 2 age groups day solicited reactogenicity xlink "> nvx older participants 60 spike protein age groups xlink ">well tolerated short duration dose regimens phase 1 older participants study confirmed second vaccination phase studies day 35 higher dose dose regimen older adults 14 days ci 21 288 participants united states trimeric full seroconversion rates safety follow randomly assigned primary endpoints predominantly mild move forward inhibitory concentration highly immunogenic higher frequencies dosing regimen current lack convalescent sera confidence interval aged 18 9 sites 84 years 8 sites 2 trial

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