Reliability and Recommended Settings for Pediatric Circumpapillary Retinal Nerve Fiber Layer Imaging Using Hand-Held Optical Coherence Tomography
To investigate feasibility and reliability of 3-dimensional full circumpapillary retinal nerve fiber layer (cpRNFL) analysis in children, with and without glaucoma, without the use of sedation and to recommend a protocol for hand-held optical coherence tomography use.A cohort of pediatric glaucoma patients and normal children were imaged with hand-held optical coherence tomography to assess the feasibility of obtaining full cpRNFL. Two consecutive scans were acquired in a smaller sample to investigate test-retest repeatability and interassessor reproducibility. The cpRNFL thickness was assessed in four quadrants, at several visual angles from the optic nerve center.Scanning was attempted in both eyes of 90 children with pediatric glaucoma and 180 controls to investigate feasibility (mean age, 6.98 ± 4.42 years). Scanning was not possible in 68 eyes of glaucoma children mainly owing to nystagmus, unclear optical media, or high refractive errors. Where three-dimensional imaging was possible, success at obtaining full cpRNFL was 67% in children with glaucoma and 89% for controls. Seventeen children with pediatric glaucoma and 34 controls contributed to reliability analysis (mean age, 6.3 ± 3.63 years). For repeatability intraclass correlation coefficients across quadrants ranged from 0.63 to 0.82 at 4° and improved to 0.88 to 0.94 at 6°. Intraclass correlation coefficients for reproducibility were also highest at 6° (>0.97 across all quadrants).We demonstrate that acquisition and measurement of cpRNFL thickness values using 3-dimensional hand-held optical coherence tomography volumes in awake children is both feasible and reliable and is optimal at 6° from optic nerve center.Our recommended protocol provides guidance on how pediatric optic nerve pathologies are managed by clinicians.
Funding
Optical coherence tomography in infants and children: A normative database and assessment of clinical use
Medical Research Council
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History
Citation
Sonal D. Shah, Adnaan Haq, Shafak Toufeeq, Zhanhan Tu, Budor Edawaji, Joseph Abbott, Irene Gottlob, Frank A. Proudlock; Reliability and Recommended Settings for Pediatric Circumpapillary Retinal Nerve Fiber Layer Imaging Using Hand-Held Optical Coherence Tomography. Trans. Vis. Sci. Tech. 2020;9(7):43. https://doi.org/10.1167/tvst.9.7.43.Author affiliation
College of Life Sciences/Psychology & Vision SciencesVersion
- VoR (Version of Record)
Published in
Translational Vision Science & TechnologyVolume
9Issue
7Pagination
43 - 43Publisher
Association for Research in Vision and Ophthalmology (ARVO)issn
2164-2591eissn
2164-2591Acceptance date
2020-05-14Copyright date
2020Available date
2020-06-30Publisher DOI
Spatial coverage
United StatesLanguage
enPublisher version
Deposited by
Dr Zhanhan TuDeposit date
2024-04-07Rights Retention Statement
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