ppat.1010994.s005.pdf (1.53 MB)
Relative change in the body mass and gross morphology of lungs excised from uninfected or infected mice showing pneumonitis and inflammation.
journal contribution
posted on 2022-12-12, 18:38 authored by Hilal Ahmad Parray, Naveen Narayanan, Sonal Garg, Zaigham Abbas Rizvi, Tripti Shrivastava, Sachin Kushwaha, Janmejay Singh, Praveenkumar Murugavelu, Anbalagan Anantharaj, Farha Mehdi, Nisha Raj, Shivam Singh, Jyotsna Dandotiya, Asha Lukose, Deepti Jamwal, Sandeep Kumar, Adarsh K. Chiranjivi, Samridhi Dhyani, Nitesh Mishra, Sanjeev Kumar, Kamini Jakhar, Sudipta Sonar, Anil Kumar Panchal, Manas Ranjan Tripathy, Shirlie Roy Chowdhury, Shubbir Ahmed, Sweety Samal, Shailendra Mani, Sankar Bhattacharyya, Supratik Das, Subrata Sinha, Kalpana Luthra, Gaurav Batra, Devinder Sehgal, Guruprasad R. Medigeshi, Chandresh Sharma, Amit Awasthi, Pramod Kumar Garg, Deepak T. Nair, Rajesh Kumar(A) Body mass of mice from each group (both prophylactic and therapeutic) was recorded for 6 days post-infection. The Y-axis represents the body mass of the mouse relative to the body mass of the same mouse recorded on day 0 (normalised to 100) (dpi, days post-infection). (B) Animal challenge experiment performed with prophylactic or therapeutic intervention of P4A2 antibody. Briefly, animals challenged with Wuhan, Kappa, Delta or Beta SARS-CoV-2 strain (105 pfu/ mice) were given prophylactic (1 day prior to challenge) or therapeutic dose (12 h post challenge) and representative images of the excised lung showing inflammation and pneumonitis.
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