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Related to Figs 2 and 4.

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posted on 2021-11-08, 18:42 authored by Francisco J. Martínez-Morcillo, Joaquín Cantón-Sandoval, Francisco J. Martínez-Navarro, Isabel Cabas, Idoya Martínez-Vicente, Joy Armistead, Julia Hatzold, Azucena López-Muñoz, Teresa Martínez-Menchón, Raúl Corbalán-Vélez, Jesús Lacal, Matthias Hammerschmidt, José C. García-Borrón, Alfonsa García-Ayala, María L. Cayuela, Ana B. Pérez-Oliva, Diana García-Moreno, Victoriano Mulero

FK-866 and olaparib improve skin epithelial integrity in psoriasis mutants. (A, B) Determination of the skin phenotype of 2.5 dpf zebrafish Atp1b1a-deficient larvae treated 1.5 days with 50 μM FK-866 or 100 μM olaparib. (C) Representative bright field images of zebrafish larvae of every group are shown. p-Values were calculated using chi-squared and Fisher exact test *p ≤ 0.05, ****p ≤ 0.0001. The data underlying this figure can be found in S1 Data.

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    sup >+reduced oxidative stressreactive oxygen speciesprecise mechanism involvedkeratinocyte dna damageinduced dna damagediv >< paifm1 nuclear translocationaifm1 axis decreasednicotinamide adenine dinucleotideinducing factor 1parthanatos cell deathpromote skin inflammationparp1 ), overexpressionchronic skin inflammationcell deathchronic inflammationlesional skinpolymerase 1nicotinamide phosphoribosyltransferasenampt ),zebrafish modelsseveral studiessalvage pathwaynadph oxidaseslimiting enzymefuels parp1associated genesaberrant induction

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