pbio.3001455.s008.pdf (190.93 kB)
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posted on 2021-11-08, 18:42 authored by Francisco J. Martínez-Morcillo, Joaquín Cantón-Sandoval, Francisco J. Martínez-Navarro, Isabel Cabas, Idoya Martínez-Vicente, Joy Armistead, Julia Hatzold, Azucena López-Muñoz, Teresa Martínez-Menchón, Raúl Corbalán-Vélez, Jesús Lacal, Matthias Hammerschmidt, José C. García-Borrón, Alfonsa García-Ayala, María L. Cayuela, Ana B. Pérez-Oliva, Diana García-Moreno, Victoriano MuleroDifferential expression profiles of genes encoding key NAD+metabolic enzymes in psoriasis. Transcriptomic data from human psoriasis (GDS4602) samples from the GEO database. Nonlesional and lesional psoriasis skin were compared with healthy skin samples. Each dot represents one individual, and the mean ± SEM for each group is also shown. p-Values were calculated using 1-way ANOVA and Tukey multiple range test (A) and t test (B). ns, not significant. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001. The data underlying this figure can be found in S1 Data. ANOVA, analysis of variance; GEO, Gene Expression Omnibus; NAD+, nicotinamide adenine dinucleotide.
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sup >+reduced oxidative stressreactive oxygen speciesprecise mechanism involvedkeratinocyte dna damageinduced dna damagediv >< paifm1 nuclear translocationaifm1 axis decreasednicotinamide adenine dinucleotideinducing factor 1parthanatos cell deathpromote skin inflammationparp1 ), overexpressionchronic skin inflammationcell deathchronic inflammationlesional skinpolymerase 1nicotinamide phosphoribosyltransferasenampt ),zebrafish modelsseveral studiessalvage pathwaynadph oxidaseslimiting enzymefuels parp1associated genesaberrant induction
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