posted on 2021-06-29, 14:33authored byJianxiong Zhou, Ruiying Wu, Xiao Fu, Jinmei Wu, Qingsong Mei
The development of precise medicine
requires diagnostic probes
to simultaneously satisfy an excellent detection limit and a wide
linear analysis range because of enormous individual-discrepancy of
disease biomarker concentrations, yet it remains challenging. Herein,
an upconverison nanoprobe with a luminescence ratio flexibly tailored
was designed for ultrasensitive monitoring exhaled nitric oxide to
indicate the clinical course of asthma. Two independent emissions
from the same nanoprobe can be discretionarily modulated to vary their
intensity ratios for adapting different analysis requirements. Delightfully,
this novel nanoprobe demonstrated a 100-fold lower detection limit
compared with the traditional ratiometric fluorescence manner and
a more broad linear detection range from the subpart per billion (ppb)
level to hundreds of ppb. This ratio-adjustable fluorescence detection
strategy holds great potential for miscellaneous disease diagnosis
applications.