posted on 2023-11-24, 00:19authored byNadia Ismaeel, Sajid Imran, Xuehua Zhu, Jue Chen, Dan Yuan, Yingming Yao
Direct thioesterification of aldehydes with thiols catalyzed
by
readily accessible rare earth/lithium amide RE[N(SiMe3)2]3(μ-Cl)Li(THF)3 is developed,
which enables the preparation of a range of thioesters (31 examples)
under room temperature and solvent-free conditions, without using
any additive or external oxidant. This method provides a straightforward
and atom-efficient approach for the thioester synthesis.