Rapid Access to 3‑Substituted
Pyridines and
Carbolines via a Domino, Copper-free, Palladium-Catalyzed Sonogashira
Cross-Coupling/6π-Aza Cyclization Sequence
posted on 2021-11-30, 19:36authored byDilipkumar Uredi, Amarender Goud Burra, E. Blake Watkins
Herein,
we report a one-pot, three-component method for the preparation
of 3-substituted pyridines and carbolines via copper-free, palladium-catalyzed
Sonogashira cross-coupling with aryl iodides, followed by 6π-aza
cyclization. This arylation cross-coupling/annulation cascade provides
easy access to substituted, fused pyridines from readily available
substrates in good yields (67–92%) with complete selectivity.