Raman spectroscopy diffusion quantification.

The methodology used to quantify the diffusion coefficient of ethanol in the tumor (DT). The experimental setup used for the Raman spectroscopy assay (left), consists of a tumor laying on a fully permeable membrane that allows seamless diffusion of ethanol upwards into the tumor. The CRS instrument captures the concentration of ethanol at the surface of the tumor over time. A deterministic transport model (right) characterizes ethanol transport and enables optimization of DT via fitting between the Raman measurements and the theoretical predictions.

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