posted on 2023-12-08, 21:45authored byYurii Shepelytskyi, Vira Grynko, Viktoriia Batarchuk, Carson L. Hasselbrink, Antal H. Kovacs, Iulian C. Ruset, Karla Rodriguez, Nedal Al Taradeh, Tanu Talwar, Brenton DeBoef, Mitchell S. Albert
Hyperpolarized
(HP) xenon-129 (129Xe) magnetic resonance
imaging (MRI) has the potential to be used as a molecular imaging
modality. For this purpose, numerous supramolecular cages have been
developed and evaluated in the past. Herein, we report a novel and
unique macrocycle that can be successfully utilized for xenon MRI,
the resorcinarene trimer methanesulfonate (R3-Noria-MeSO3H). This molecule is capable of two different contrast mechanisms
for xenon-MRI, resulting from an increase in the effective spin–spin
relaxation and hyperpolarized chemical exchange saturation transfer
(HyperCEST). We have demonstrated a superior negative contrast caused
by R3-Noria-MeSO3H on HP 129Xe MRI at 3.0 T
as well as HyperCEST imaging of the studied macrocycle. Additionally,
we have found that the complex aggregation behaviors of R3-Noria-methanesulfonate
and its impact on xenon-129 relaxivity are an area for future study.