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Quantile-Quantile plot for AA-DHS by trait.

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posted on 2021-05-20, 17:54 authored by Nicholette D. Palmer, Lingyi Lu, Thomas C. Register, Leon Lenchik, J. Jeffrey Carr, Pamela J. Hicks, S. Carrie Smith, Jianzhao Xu, Latchezar Dimitrov, Jacob Keaton, Meijian Guan, Maggie C. Y. Ng, Yii-der I. Chen, Anthony J. Hanley, Corinne D. Engelman, Jill M. Norris, Carl D. Langefeld, Lynne E. Wagenknecht, Donald W. Bowden, Barry I. Freedman, Jasmin Divers

Each black dot represents an observed statistic [log10(P)] (y-axis) versus the corresponding expected statistic (x-axis). The red line denotes the null distribution, which assumes no association. Corresponding inflation factors (λ) are listed for each trait. A. 25-hydroxyvitamin D (λ = 1.01), B. 1,25-dihydroxyvitamin D (λ = 1.01), C. Vitamin D Binding Protein (λ = 1.03), D. Bioavailable Vitamin D (λ = 1.02), E. intact Parathyroid Hormone (λ = 1.01), F. thoracic volumetric bone mineral density (λ = 1.02), G. lumbar volumetric bone mineral density (λ = 1.02).

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    2 D 325 OHDIRASFSAfrican Americans2.2 x 10 -10Insulin Resistance Atherosclerosis ...vitamin D binding proteinHSPGbone mineral density phenotypesBMDAmerican-Diabetes Heart Study parti...type 2 diabetesvitamin D metabolismTNIKAfrican American-Diabetes Heart StudyBAVDT 2Dbioavailable vitamin DAfrican American populationSE9.4 x 10 -86Genome-wide association studyvitamin D concentrationsbone mineral density3.5 x 10 -08variant3.3 x 10 -19VDBPGC

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