posted on 2021-02-12, 19:34authored byAnna R. Kaplan, Djamaladdin G. Musaev, William M. Wuest
Pseudomonads employ
several strategies to sequester
iron vital for their survival including the use of siderophores such
as pyoverdine and pyochelin. Similar in structure but significantly
less studied are pyochelin biosynthetic byproducts, dihydroaeruginoic
acid, aeruginoic acid, aeruginaldehyde (IQS), and aeruginol, along
with two other structurally related molecules, aerugine and pyonitrins
A–D, which have all been isolated from numerous Pseudomonad extracts. Because of the analogous substructure of these compounds
to pyochelin, we hypothesized that they may play a role in iron homeostasis
or have a biological effect on other bacterial species. Herein, we
discuss the physiochemical evaluation of these molecules and disclose,
for the first time, their ability to bind iron and promote growth
in Pseudomonads.