ppat.1012045.s013.docx (20.27 kB)

Putative CRL subunits in apicomplexan parasites.

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posted on 2024-02-28, 18:34 authored by Zeba Rizvi, G. Srinivas Reddy, Somesh M. Gorde, Priyanka Pundir, Divya Das, Puran Singh Sijwali

PfCullin-1, PfCullin-2, PfRbx1 and PfSkp1 homologs in reference apicomplexan parasite strains of different families.

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wd40 repeat proteins ubiquitin e3 ligases significantly lower number significantly decreased asexual poorly delimited merozoites largest group among internal membraned structures likely reflects association div >< p different cellular compartments contains functional scf ubiquitination assay indicated ubiquitination assay confirmed including protein translation calcyclin binding protein pfcrl4 ), consisting including cell division human malaria parasite crls remain underappreciated 2 ), rbx1 maintaining membrane integrity functional human crl4 plasmodium falciparum 1 ), cullin cell division membrane integrity plasmodium p falciparum functional crls chromatin association cellular homeostasis protein ubiquitination genome integrity vitro protein levels protein level protein interaction protein degradation several processes several pathways sequence analysis schizont stages related parasites predominantly expressed nucleocytoplasmic localization normal parasites multiple pathways model eukaryotes lipid biosynthesis functional skp1 erythrocytic trophozoite depleted schizonts depleted parasites associated processes although conserved 2 knock 2 forms 2 depletion

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