Pulmonary pathology of SARS-CoV-2 infected K18-hACE2 mice in therapeutic group.
journal contribution
posted on 2022-12-12, 18:39 authored by Hilal Ahmad Parray, Naveen Narayanan, Sonal Garg, Zaigham Abbas Rizvi, Tripti Shrivastava, Sachin Kushwaha, Janmejay Singh, Praveenkumar Murugavelu, Anbalagan Anantharaj, Farha Mehdi, Nisha Raj, Shivam Singh, Jyotsna Dandotiya, Asha Lukose, Deepti Jamwal, Sandeep Kumar, Adarsh K. Chiranjivi, Samridhi Dhyani, Nitesh Mishra, Sanjeev Kumar, Kamini Jakhar, Sudipta Sonar, Anil Kumar Panchal, Manas Ranjan Tripathy, Shirlie Roy Chowdhury, Shubbir Ahmed, Sweety Samal, Shailendra Mani, Sankar Bhattacharyya, Supratik Das, Subrata Sinha, Kalpana Luthra, Gaurav Batra, Devinder Sehgal, Guruprasad R. Medigeshi, Chandresh Sharma, Amit Awasthi, Pramod Kumar Garg, Deepak T. Nair, Rajesh KumarLung samples from euthanized animals 6 days post challenge were fixed in 10% formalin solution and stained with H & E. (A) Representative transverse section of the H & E stained lung images at 40× magnification showing pneumonitis (red arrow), alveolar epithelial injury (blue arrow) and inflammation (black arrow). The stained sections were assessed by blinded-trained histologist on the scale of 0–5 (where 0 represents no feature, while 5 represents the maximum score). (B) The histological scores for each pulmonary pathology was plotted as mean ± SEM. The disease index score was calculated by taking the average score of all pulmonary pathologies. Ther, therapeutic; NS, not statistically significant.
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