ppat.1009773.s005.docx (17.67 kB)
Pulmonary TB in progressor DO mice reflects acute inflammation, neutrophil recruitment and activation, and extracellular matrix degradation.
journal contribution
posted on 2021-08-17, 17:32 authored by Deniz Koyuncu, Muhammad Khalid Khan Niazi, Thomas Tavolara, Claudia Abeijon, Melanie L. Ginese, Yanghui Liao, Carolyn Mark, Aubrey Specht, Adam C. Gower, Blanca I. Restrepo, Daniel M. Gatti, Igor Kramnik, Metin Gurcan, Bülent Yener, Gillian BeamerEnrichr identified the following gene ontology pathways using a set of 119 genes that were highly expressed in the lungs of progressor DO mice compared to non-infected DO mice and to controller DO mice. GO terms with adjusted p < 0.01 are shown, along with the human homologs of the genes overlapping with the term. Expressed genes in bold were pursued as diagnostic biomarkers.
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targeted product profilemachine learning methods239 protein subsetsprotein biomarker pipelineone protein biomarkerserum protein biomarkershuman serum samplesmillions still diehelp diagnose tbdiagnose active tbactive pulmonary tbnew diagnostic biomarkertb lung diseasefindings overall showdiv >< pcxcl1 averaged 94ltbi ), nonatb vs nonvs ltbibiomarker candidatesserum cxcl129 noninfectious diseaseafflicts millionsdiscover diagnosticdiagnostic performancewidely assessedusing areatriage testtb specificity ),south africapatient seranormal seramouse populationfive algorithmsexperts advocatediversity outbredcxcl1 exceededcurve analysesburden countriesapplied statistical453 infected
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