pntd.0009511.s007.pdf (155.06 kB)
Published data on antimalarials that report drug activity against S. mansoni.
journal contribution
posted on 2021-06-24, 17:42 authored by Erik Koehne, Nina Zander, Miriam Rodi, Jana Held, Wolfgang Hoffmann, Rella Zoleko-Manego, Michael Ramharter, Ghyslain Mombo-Ngoma, Peter G. Kremsner, Andrea KreidenweissAll data are expressed in molarity and were converted (*) if necessary. WBR Worm burden reduction, LD: lethal dose, d: days, n.d.: no data was found in the literature.
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Pyronaridine treatmentTrial registration ClinicalTrials.g...10 μ Mworm burdenmalaria parasitesprepatent stagespatient managementalternative treatment strategies1 controlSchistosoma Background Schistosomiasis30 μ Madult schistosomeshaematobium egg excretionantischistosomal compoundsantimalarial pyronaridineSchistosoma infectionsstage schistosomulaResults Amongst 16 drugsantiplasmodial compoundsmethyleneprepatent stagepilot trialantimalarial drugvivo activityschistosomiasis treatmentdrug resistance12 animalsConclusion Pyronaridineantimalarial drug combination pyron...4 childrenvivo adult wormsmice adult stagesschistosome infectionsadult worms
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