pgen.1009784.s003.pdf (107.17 kB)
Proportion of different junction types is not proportional to available DNA during library preparation.
journal contribution
posted on 2021-08-31, 17:31 authored by David A. Ellis, Félix Reyes-Martín, María Rodríguez-López, Cristina Cotobal, Xi-Ming Sun, Quentin Saintain, Daniel C. Jeffares, Samuel Marguerat, Víctor A. Tallada, Jürg BählerPie charts showing numbers of junctions between mitochondrial and nuclear (green), mitochondrial and mitochondrial (purple), and nuclear and nuclear (orange) DNA in simulated data (left, based on read depth at mitochondrial DNA and nuclear chromosomes) and in measured data (right).
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small genetic variantssir2 histone deacetylasesingle diagnostic measureschizosaccharomyces pombe remote breakpoints elsewherereflect individually rarefindings provide insightsdetected similar signaturesdividing cell populationsde novo old brain cellsdiv >< pdna breakpoint junctionsaberrant dna junctionsdrive genome rearrangementscharacterize genome rearrangementsassociated breakpoint formationbreakpoint junctionsdividing cellsmitochondrial dnagenome rearrangementsdna doubledependent deaberrant repairproliferating cellsunique patternsunexpected mechanismtarget locistrand breaksresult suggestsrelated changesregulatory changesrandom patternspossible mechanismsmodel systemmitochondrial chromosomemicrohomology sequenceslocal hotspotsheterogeneous eventsglobal hotspotsgenomic instabilitygenomic distributionchromatin silencingbiological processesassociated reduction
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