posted on 2021-08-06, 06:43authored byKe Wen, Chuntian Hu, Wei Wu, Khrystyna Shvedova, Stephen C. Born, Bayan Takizawa, Salvatore Mascia
In the continuous manufacturing of
pharmaceuticals, in-line monitoring
and control are essential. Many pharmaceutical manufacturing processes
require pH adjustment. Here, an in-line pH neutralization system with
both coarse and fine adjustments was designed, and promising results
were obtained. In nonbuffered conditions, the proposed two-pump system
was able to control the fluctuations within approximately 2 pH units
near the equivalence point, for both aqueous solutions and organic–H2O mixtures with strong acid.