Predicted drug-like features for NF2836, NF2838 and NF2839 compounds.

^aSASA predicted the total solvent accessible surface (range or recommended value for 95% of known drugs 300–1000); ^bQPlogP predicted octanol/water partition coefficient (range or recommended value for 95% of known drugs -2–6.5); ^cQPlogS predicted aqueous solubility in mol/dm³(range or recommended value for 95% of known drugs -6.5–0.5); ^dQPPCaco predicted apparent Caco-2 cell permeability in nm/sec (range or recommended value for 95% of known drugs >500 great); ^eQPPMDCK predicted apparent MDCK cell permeability in nm/sec (range or recommended value for 95% of known drugs >500 great); ^fQPlogHERG predicted IC₅₀ values for blockage of HERG K⁺ channels (range or recommended value for 95% of known drugs below -5); ^g%HOA predicted human oral absorption on 0 to 100% scale (range or recommended value for 95% of known drugs >80% high). Range or recommended values are reported in QikProp user manual. *Cmpd name reported in Relitti et al [25].

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