posted on 2023-12-01, 11:03authored bySoumya
Jyoti Basak, Jyotirmayee Dash
In this study, we present a novel and cost-effective
approach for
synthesizing biologically significant analogues of rutaecarpine alkaloid
through a one-step cascade reaction. The pentacyclic core of rutaecarpine
alkaloid analogues is efficiently constructed using 2-aminobenzonitriles
and substituted indole-2-carbaldehydes in the presence of the affordable
base KOtBu. The salient feature of this
approach is the promotion of a sequential cascade process within a
single reaction vessel including the formation of a dihydroquinazolinone
ring, oxidation, and cyclization. This method can be successfully
applied on a larger scale, making it economically viable.