posted on 2021-08-30, 07:15authored byReza Gharibi, Seema Agarwal
The
present work considers designing bioactive and biocidal thermoplastic
PU materials with inherent fast and nonleaching antibacterial activity
to address their present shortcomings in biomedical applications.
For this, we have prepared a series of multiapplicable guanidine-modified
thermoplastic polyurethane by grafting different amounts of polyguanidine
to the uretdione-containing thermoplastic polyurethane. Our conceptually
unique design generates PHMG-UPUs that offer a broad range of physicomechanical
properties from hydrophobic elastic polyurethane materials to highly
elastic hydrogels that could meet the requirements of different applications,
including antibacterial coating, biomedical devices (catheters), and
wound dressing. All materials displayed fast and efficient contact-active
biocidal activity against Gram-negative and Gram-positive bacteria
and superior antibiofilm activity. The support of fibroblast cell
growth and moderate-to-excellent cell viability ranging from 95 to
∼65% is also observed. This study introduces a prospective
strategy to tune the mechanical and biological properties of thermoplastic
polyurethane for various biomedical applications in a simple way.