posted on 2021-11-29, 19:05authored byDaeYong Lee, JongHoon Ha, Hyomin Ahn, Seong Dong Jeong, MoonKyoung Jeong, Ji-Ho Park, Chae-Ok Yun, Yeu-Chun Kim
Immunogenic
cell death (ICD) is a key factor for generating antitumor
immunity. Endoplasmic reticulum (ER) stress triggers the release of
damage-associated molecular patterns (DAMPs), thus inducing immunogenicity.
We developed a polypeptide-based K+ ionophore that perturbed
ion homeostasis and elicited a prolonged ER stress. The ER stress
not only fosters an oxidative environment that activates mitochondria-dependent
apoptosis pathways but also drives immune responses by releasing DAMPs.
The ionophore suppressed tumor proliferation in vitro and in vivo
based on the pro-apoptotic activity and immunogenicity.