posted on 2024-02-07, 05:03authored byYuansheng Li, Yu Cheng, Yuankun Wu, Zixi Wang, Xiang Ma, Jian Zhao, Ziyi Yang, Yuanhui Ji
Chemo–photothermal combination
therapy is an emerging clinical
treatment method, which shows favorable application prospects in clinical
practice. However, various drug delivery systems have certain disadvantages,
and it is urgent to overcome the existing disadvantages and combine
the advantages of different delivery systems. In this study, we have
designed and synthesized a novel core–shell polymer-coated
lipid-core nanoparticle drug delivery system for chemo–photothermal
therapy. The designed drug delivery system is based on electrostatic
self-assembled polylysine-lecithin (PLL-LC) lipid nanoparticles to
encapsulate antitumor or anti-inflammatory drugs and then coated with
polydopamine (PDA) shell for chemo–photothermal combination
therapy. The self-polymerized PDA coated on the surface of nanomicelles
under weak alkaline conditions can form a responsive drug delivery
system. As expected, the prepared core–shell nanoparticles
showed good photothermal properties and good potential for thermal
ablation of tumor cells. Moreover, the release of chemotherapeutic
drugs under the modification of polydopamine has the corresponding
pH and NIR stimulation. In vitro drug release and cell experiments
demonstrated that our designed nanoparticles could achieve pH- and
NIR-stimulation-responsive drug release and exhibit enhanced tumor
cytotoxicity under laser irradiation. Taken together, our study demonstrates
that designed nanoparticles can be used for pH/NIR-responsive sustained
release and chemo–photothermal synergistic treatment.