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Physicochemical properties, water solubility and pharmacokinetics predicted data for benzazepinones and paullones tested in biological assays.

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posted on 2023-11-30, 18:24 authored by Irina Ihnatenko, Marco J. Müller, Oliver C. F. Orban, Jens C. Lindhof, Diego Benítez, Cecilia Ortíz, Estefanía Dibello, Leonardo L. Seidl, Marcelo A. Comini, Conrad Kunick

Physicochemical properties, water solubility and pharmacokinetics predicted data for benzazepinones and paullones tested in biological assays.

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    target trypanothione synthetasepotentially fatal outcomesdiverse benzazepinone derivativesdiv >< pdiseases affect peoplebesides insufficient diagnosticsadequate health carenew compounds lackingnew antitrypanosomal antiinfectivesindole moiety showedclass kinetoplastea ).leishmania infantum new compoundsleishmania infantum compound classsar ).antitrypanosomal activitytrys ).trypanosoma treatment optionstotal losstenuous developmentstb severe infectionsremote areasrecent yearspresented approachpreceding studiespotent inhibitorspaullones ledpathogen survivalli l intracellular amastigotesindole motifexamined regardingbrucei b

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