posted on 2024-02-09, 14:11authored byJie Gao, Xian-Chen He, Yan-Ling Liu, Pin-Pin Yao, Jian-Ping Guan, Kai Chen, Hao-Yue Xiang, Hua Yang
Herein, a dual photoredox/nickel
catalyzed formylation of aryl
bromide with commercially available 2,2-dimethoxy-N,N-dimethylethan-1-amine as an effective CO source
has been successfully achieved, delivering a series of aromatic aldehydes
in moderate to good yields. Compared with the traditional reductive
carbonylation process, this newly designed synthetic protocol provides
a straightforward toolbox to access aromatic aldehydes, obviating
the use of carbon monoxide and stoichiometric reductants. Finally,
the utility of this direct formylation reaction was demonstrated in
the pharmaceutical analogue synthesis.