posted on 2024-02-04, 18:04authored byMark C. Maust, Simon B. Blakey
Modern organic synthesis requires methodologies that
bring together
abundant feedstock chemicals in a mild and efficient manner. To aid
in this effort, we have developed a multicomponent radical hydroxyarylation
reaction that utilizes aryl halides, olefins, and O2 as
the reaction components. Crucial to this advance was an oxidative,
rather than a reductive, approach to aryl radical generation, which
enables reaction tolerance to O2. This methodology displays
a broad functional group tolerance with a variety of functionalized
aryl halides and a broad array of olefins. Development of this methodology
enables rapid access to biologically relevant hydroxyaryl products
from simple, commercially available starting materials.