A simple
and mild photoredox catalytic approach to access difluoroalkylated
dioxodibenzothiazepines in high regioselectivity via radical cascade
cyclization has been described herein. In contrast to previous methods,
this strategy does not involve the use of transition-metal catalysts
and avoids the potential disadvantages of inevitable toxicity and
the tedious removal process of metal catalysts. The commercially available
and inexpensive CF2 precursors, wide substrate scope, and
mild reaction conditions demonstrate the practicability of this approach.