posted on 2024-01-22, 18:33authored byRamon Arora, Mark Lautens
A nickel/blue
light-catalyzed carbohalogenation reaction is reported.
A nickel catalyst and an inexpensive phosphine ligand promote the
reaction of aryl iodides and aryl bromides with π systems to
enable the construction of a library of halogenated heterocyclic scaffolds.
Mechanistic studies provide insight regarding fundamental steps of
the catalytic cycle, including the reversible C–X bond formation
via deuterium labeling and EPR experiments, while preliminary enantioselective
results suggest a two-electron migratory insertion.