posted on 2022-12-16, 20:34authored byBaptiste Picard, Takahide Fukuyama, Ilhyong Ryu
An improved carbonylation method allowing amide bond
formation
between aryl iodides and aromatic amines is presented. In contrast
to usual methods based on Pd catalysis, this method does not require
a phosphine ligand. The catalyst system simply employs bis(dibenzylideneacetone)palladium
(0.5 mol %) and DBU (10 mol %). The method was applied to the synthesis
of various aromatic amides from aryl iodides and amines, and was scaled
to gram order synthesis under as low as 1 atm of carbon monoxide.