Pd/Cu-Catalyzed Domino Cyclization/Deborylation of
Alkene-Tethered Carbamoyl Chloride and 1,1-Diborylmethane

Zhang, Chenhuan; Wu, Xianqing; Wang, Chenchen; Zhang, Chengxi; Qu, Jingping; Chen, Yifeng

doi:10.1021/acs.orglett.0c02211.s001

ol0c02211_si_001.pdf (7.07 MB)

Pd/Cu-Catalyzed Domino Cyclization/Deborylation of Alkene-Tethered Carbamoyl Chloride and 1,1-Diborylmethane

journal contribution

posted on 2020-08-05, 18:35 authored by Chenhuan Zhang, Xianqing Wu, Chenchen Wang, Chengxi Zhang, Jingping Qu, Yifeng Chen

Reported herein is a palladium/copper cooperative-catalyzed dicarbofunctionalization of alkene-tethered carbamoyl chlorides with 1,1-diborylmethane. This cyclization/deborylation cascade strategy allows for the expedient formation of the versatile borylated 3,3-disubstituted oxindole skeleton, allowing for further functionalization via the derivatization of the carbon–boron bond.