pntd.0010149.s003.docx (1.94 MB)
Pathological changes in the contralateral feet during the acute stage.
journal contribution
posted on 2022-01-31, 18:22 authored by Yue Zhang, Hu Yan, Xian Li, Dihan Zhou, Maohua Zhong, Jingyi Yang, Bali Zhao, Xuxu Fan, Jun Fan, Jiayi Shu, Mengji Lu, Xia Jin, Ejuan Zhang, Huimin YanNeonate C57BL/6 mice (6–8 days old) were infected by intradermal injection with 10 PFU, 102 PFU, and 106 PFU of CHIKV. (A) H&E staining of paraffin-embedded sections of contralateral feet was examined at 6 dpi. (B) H&E staining of paraffin-embedded sections of contralateral feet was also examined at 29 dpi. Original images are shown at low magnification (×50) and high magnification (×200). n = 5 per group.
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chronic debilitating polyarthralgiadependent viral rnalow copy numbersskeletal muscle damagechronic tissue damagediv >< ppersistent viral infectionacute viral infection6 persistent chikv infectionacute infectionpersistent chikvviral relapseviral persistencechikv infectionlow levelacute fever6 miceuseful tooltype c57bltransmitted alphavirustaken togetherspecific cd8results provideresults demonstratedreadily establishedprogressive reductionpresent studypathological featuresnewborn wildinoculation dosefootpad inoculationfoot tissuesfoot jointsemerging mosquitodoses rangingcontinuously detectablecell responsesbriefly repaired50 dpi50 days
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