posted on 2024-01-26, 19:46authored bySonbidya Banerjee, Tharmalingam Punniyamurthy
Palladium-catalyzed
weak-chelation-assisted C4-selective nitration
of indoles has been accomplished employing tert-butyl
nitrite in the presence of oxone under molecular oxygen at a moderate
temperature. Aerobic conditions, C4-selectivity, substrate scope,
conversion to valuable aminated indoles, and late-stage natural product
modifications are the important practical features.