pcbi.1009563.s008.pdf (421.04 kB)
Pairwise colocalization of GWAS signals at chr7q32.2.
journal contribution
posted on 2021-11-18, 18:57 authored by Jason W. Hoskins, Charles C. Chung, Aidan O’Brien, Jun Zhong, Katelyn Connelly, Irene Collins, Jianxin Shi, Laufey T. Amundadottir(A) LocusCompare plot of chr7q32.2 locus variants’ -log10(P) from BMI GWAS versus T2D (BMI-adjusted) GWAS. Points are colored according to the variant’s r2 with the reference variant, which is marked by the purple diamond. Posterior probability (PP) of a single, shared functional variant was calculated with HyPrColoc. (B) Same as A, but for BMI GWAS versus HDL GWAS. (C) Same as A, but for BMI GWAS versus Triglycerides GWAS. (D) Same as A, but for T2D (BMI-adjusted) GWAS versus HDL GWAS. (E) Same as A, but for T2D (BMI-adjusted) GWAS versus Triglycerides GWAS. (F) Same as A, but for HDL GWAS versus Triglycerides GWAS.
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wide association studyregulators whose activitiesphenotypic master regulatorsdiv >< pdetect activity qtls35 bmi mrtarget network interactionsephb2 cis gwas signal mayephb2 cis different regulatorsphenotypic mrsgwas signalbmi mrs>- qtlstarget overlaptarget genestrans regulator activitiesviper algorithmmrs ),integrates enrichmentexpression qtlbroadly applied>- aqtl
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