pntd.0009999.s011.docx (16.84 kB)

Overview of study population.

journal contribution

posted on 2021-11-29, 18:59 authored by Ole Lagatie, Emmanuel Njumbe Ediage, Dirk Van Roosbroeck, Stijn Van Asten, Ann Verheyen, Linda Batsa Debrah, Alex Debrah, Maurice R. Odiere, Ruben T’Kindt, Emmie Dumont, Koen Sandra, Lieve Dillen, Tom Verhaeghe, Rob Vreeken, Filip Cuyckens, Lieven J. Stuyver

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macrofilaricide clinical trials invasive tests available epidemiological transmission studies enable pharmacodynamic studies div >< p current estimates indicate 17 million people targeted validation study specific lipid features mda efficacy surveys lymphatic filariasis cases 20 individuals ).multimodal biomarker discovery detect ongoing infection infected individuals (<onchocerca volvulus plasma metabolites inosine urine metabolite ccg infected cases volvulus targeted lc specific cutoffs associated metabolites 8 individuals 68 individuals infected worldwide efficacy biomarkers work resulted urine metabolite surrogate endpoints subsequent evaluation specificity profiles river blindness palpable nodules ms procedures identify onchocerciasis full potential filarial nematode filarial infection endemic population endemic controls elimination programs elevated concentrations effective monitoring cis based approach >- cinnamoylglycine 7 ng 2 ng 1380 ng

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