posted on 2023-12-08, 17:20authored byHao Wang, Jiajin Xue, Ying Li, Keda Shi, Jiaru Fang, Jilin Zheng, Xuelian Lyu, Zhigang Gao, Dongxin Xu, Ning Hu
Nanostructures are powerful components
for the development
of high-performance
nanodevices. Revealing and understanding the cell–nanostructure
interface are essential for improving and guiding nanodevice design
for investigations of cell physiology. For intracellular electrophysiological
detection, the cell–nanostructure interface significantly affects
the quality of recorded intracellular action potentials and the application
of nanodevices in cardiology research and pharmacological screening.
Most of the current investigations of biointerfaces focus on nanovertical
structures, and few involve nanoconcave structures. Here, we design
both nanoconvex and nanoconcave devices to perform intracellular
electrophysiological recordings. The amplitude, signal-to-noise ratio,
duration, and repeatability of the recorded intracellular electrophysiological
signals provide a multifaceted characterization of the cell–nanostructure
interface. We demonstrate that devices based on both convex and concave
nanostructures can create tight coupling, which facilitates high-quality
and stable intracellular recordings and paves the way for precise
electrophysiological study.