One-Pot Synthesis
of Polycyclic Sultams Enabled by
Gold-Catalyzed Hydroamination of o‑Alkynylbenzenesulfonamides
and Subsequent Iodine(III)-Mediated Counteranion-Assisted Intramolecular
Annulation
posted on 2024-03-08, 18:42authored byLijun Zhang, Zhiguang Song
Herein we present a facile and efficient one-pot synthetic
protocol
for the construction of polycyclic sultams. This protocol involves
gold-catalyzed intramolecular hydroamination of o-alkynylbenzenesulfonamides followed by HTIB-mediated counteranion-assisted
intramolecular annulation. The transformation tolerates a wide range
of functional groups, resulting in the formation of highly functionalized
and valuable polycyclic sultam skeletons in moderate to excellent
yields. These polycyclic sultams are widely used as key building blocks
in organic science.