One-Carbon Homologation of Carboxylic Acids via BtCH2TMS:  A
Safe Alternative to the Arndt−Eistert Reaction

Katritzky, Alan R.; Zhang, Suoming; Hussein, Abdel Haleem Mostafa; Fang, Yunfeng; Steel, Peter J.

doi:10.1021/jo0017640.s001

jo0017640_si_001.pdf (956.33 kB)

One-Carbon Homologation of Carboxylic Acids via BtCH₂TMS: A Safe Alternative to the Arndt−Eistert Reaction

journal contribution

posted on 2001-07-18, 00:00 authored by Alan R. Katritzky, Suoming Zhang, Abdel Haleem Mostafa Hussein, Yunfeng Fang, Peter J. Steel

Carboxylic acids are converted into the corresponding homologated acids or esters, using easily available 1-(trimethylsilylmethyl)benzotriazole (1) as a one-carbon synthon. The effectiveness of the reaction has been investigated on six aryl and seven alkyl carboxylic acids.