pone.0258601.s002.docx (41.59 kB)
Number of responders and non-responders at maximum effect and measurement points in High/Low-IFX group.
journal contribution
posted on 2021-10-13, 17:33 authored by Kazuto Nakae, Sho Masui, Atsushi Yonezawa, Motomu Hashimoto, Ryu Watanabe, Koichi Murata, Kosaku Murakami, Masao Tanaka, Hiromu Ito, Kotoko Yokoyama, Noriko Iwamoto, Takashi Shimada, Miyuki Nakamura, Masaya Denda, Kotaro Itohara, Shunsaku Nakagawa, Yasuaki Ikemi, Satoshi Imai, Takayuki Nakagawa, Makoto Hayakari, Kazuo MatsubaraThe cut-off value was determined to be at serum IFX level ≥1.0 μg/mL. Responders had “good and moderate responses” and non-responders had “no responses” based on the EULAR response criteria. Values were considered statistically significant at a p value less than 0.05, based on two-sided Fisher’s exact test. Abbreviations: EULAR, European League Against Rheumatism; IFX, infliximab.
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xlink "> infliximabtandem mass spectrometermaximum effect pointjapanese cohort databasealthough previous studiesbetter therapeutic responseserum ifx levelshigh ifx groupshigh ifx grouprheumatoid arthritis management32 956311 ra patientsifx measurement pointretrospective study basedlow ifx grouprheumatoid arthritisra ).patients stillml basedmeasurement pointsused ifxifx introductiontherapeutic efficacysignificantly higherresponder proportionsrespond adequatelypotential applicationspotential applicationoptimal cutmeasured usingliquid chromatographyjanuary 1december 31considerably improvedcollected retrospectivelyclinical practice9 ).
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